Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-01-30
2007-01-30
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S069100, C435S071100, C435S091100, C435S091200, C435S212000
Reexamination Certificate
active
10401251
ABSTRACT:
The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing machinery. Markers may comprise cleavable moieties, detectable labels, reporter properties wherein markers incorporated into protein can be distinguished from unincorporated markers, or coupling agents which facilitate the detection and isolation of nascent protein from other components of the translation system. The invention also comprises proteins prepared using misaminoacylated tRNAs which can be utflized in pharmaceutical compositions for the treatment of diseases and disorders in humans and other maninials, and kits which may be used for the detection of diseases and disorders.
REFERENCES:
patent: 5643722 (1997-07-01), Rothschild et al.
patent: 6566070 (2003-05-01), Rothschild et al.
patent: 6949341 (2005-09-01), Rothschild et al.
Olejnik Jerzy
Rothschild Kenneth J.
Sonar Sanjay M.
Ketter James
Medlen & Carroll LLP
The Trustees of Boston University
LandOfFree
Detection of disease related genes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Detection of disease related genes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of disease related genes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3825234