Detection of CD8+ T cell responses to M. tuberculosis

Details Detection of CD8+ T cell responses to M. tuberculosis Detection of CD8+ T cell responses to M. tuberculosis

2006-10-03

2006-10-03

Swartz, Rodney P (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C424S009100, C424S009200, C424S184100, C424S185100, C435S325000, C435S363000, C435S372000, C435S374000, C436S501000, C530S300000, C530S350000

Reexamination Certificate

active

07115361

ABSTRACT:
A method of detecting an anti-mycobacterial CD8 T cell response comprising contacting a population of CD8 T cells of an individual with one or more peptides selected from the peptides represented by SEQ ID NO: 3, 4, 7, 8, 9, 10, 11 or 12, and, optionally, one or two further peptides represented by SEQ ID NO: 1 and/or 2, wherein one or more of said peptides may be substituted by an analogue which binds a T cell receptor which recognises the corresponding substituted peptide, and determining whether CD8 T cells of the CD8 T cell population recognize the peptide(s).The invention also provides a method of vaccinating against infection by amycobacterium, wherein the vaccination leads to a CD8 T cell response, comprising administering (i) a CD8 T cell epitope of amycobacteriumprotein, (ii) an analogue of the epitope which is capable of inhibiting the binding of the epitope to a T cell receptor, (iii) a precursor or (i) or (ii) which is capable of being processed to provide (i) or (ii), or (iv) a polynucleotide which is capable of being expressed to provide (i), (ii) or (iii).

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