Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-12-16
1996-08-06
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 435 912, 536 235, 536 2431, 536 2433, 536 253, 935 76, 935 77, C12Q 168, C12P 1934, C07H 1204, C12N 1500
Patent
active
055432964
ABSTRACT:
Methods are provided for detecting carcinoma metastases in selected body tissues and fluids. These methods offer greater than 1,000-fold enhanced sensitivity compared to prior standard diagnostic methods. In one embodiment of the invention, target carcinoma associated nucleic acid sequences are identified for detecting minimal residual disease in lung carcinomas. The methods utilize nucleic acid amplification techniques, preferably, the polymerase chain reaction.
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Green Mark R.
Kawasaki Ernest S.
Sobol Robert E.
Gould George M.
Hoffman-La Roche Inc.
Petry Douglas A.
Regents of the University of California
Sias Stacey R.
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