Detection of cancer associated polypeptide antigen and preparati

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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260112R, 260112B, 2601125, 260121, 424 8, 424 85, 424 88, 424 95, 424177, A61K 3700, A61K 3900, C07G 700, G01N 3100

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active

041600193

ABSTRACT:
A process for the isolation of cancer associated polypeptide antigen mainly by several steps of gel filtration and pH-gradient elution; a cancer associated polypeptide antigen based on a single peptide chain and denaturating irreversibly at pHs exceeding about 4.5; a composition comprising such antigen and a stabilizing amount of albumen in admixture therewith and a method of making such composition; a diagnostic composition comprising a particulate material labelled with albumen-stabilized antigen; process for preparing antibodies monospecific with regard to the cancer associated polypeptide antigen comprising preparing an oil emulsion, wherein an acid aqueous solution of the polypeptide is enclosed phase protected by a surrounding oil phase; a cancer diagnosis method based on determining the presence of cancer associated polypeptide antigen in a living animal body under examination; and composition useful as an immunizing agent containing as an active ingredient the cancer associated polypeptide antigen.

REFERENCES:
patent: 3823126 (1974-07-01), Bjorklund
patent: 3968827 (1976-06-01), Bjorklund
Bjorklund, Immuno. Techniq. for Detection of Cancer, 1973, pp. 193-194, 237-247, Bonniers, Stockholm, Sweden.
Bjorklund, Int. Arch. Allergy, vol. 8, 1956, pp. 179-192.
Bjorklund, Int. Arch. Allergy, vol. 36, 1969, pp. 191-203.
Bjorklund, reprint from Protides of the Biological Fluids, 24th Colloquium, Bruges, 1975, Pergamon Press, Oxford, 1976, pp. 505-512.
Bjorklund, reprint from J. Nat. Cancer Inst., vol. 26, March 1961, pp. 533-545.
Bjorklund, reprint from Analytical Biochem., vol. 41, No 1, May 1971, pp. 287-290.
Bjorklund, reprint from The Relic. Sys. in Health & Dis:Immuno & Path. Aspects, (1976), Plenum Pub., N.Y., pp. 357-370.
Bjorklund, reprint from Onco-Developmental Gene Expression, Acad. Press, N.Y., 1976, pp. 501-508.

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