Detection of cancer and precancerous conditions in tissues and/o

Details Detection of cancer and precancerous conditions in tissues and/o Detection of cancer and precancerous conditions in tissues and/o

1998-01-23

2000-07-18

Smith, Ruth S.

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

600477, 436 63, 436 64, 436172, A61B 500

Patent

active

06091985&

ABSTRACT:
A method of detecting cancer or precancerous conditions in a tissue or cell using fluorescence excitation spectroscopy. According to one embodiment of the method, a tissue is tested for cancer or a precancerous condition by exciting the tissue with substantially monochromatic light at 268 nm and then at 289 nm, with the resultant native fluorescence emitted from the tissue following each excitation being measured. A ratio of the fluorescence intensities, e.g., I.sub.289 /I.sub.268, is then calculated. If I.sub.289 /I.sub.268 is greater than 1.5, the tissue is cancerous or precancerous whereas if I.sub.289 /I.sub.268 is less than 1.5, the tissue is not cancerous or precancerous.

REFERENCES:
patent: 4270924 (1981-06-01), Crooke et al.
patent: 5131398 (1992-07-01), Alfano et al.
patent: 5456260 (1995-10-01), Kollias et al.
patent: 5635402 (1997-06-01), Alfano et al.
patent: 5697373 (1997-12-01), Richards-Kortum et al.

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