Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-02-28
2006-02-28
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S518000, C436S524000, C436S525000, C422S082010, C422S068100, C204S194000, C204S400000, C204S403100, C204S230700
Reexamination Certificate
active
07005268
ABSTRACT:
A method for detecting the presence of target molecules bound to a working electrode in a first location. The first location is coated with a detection solution containing labeling molecules that include a first charge-separation moiety attached to a first molecule that binds to the target molecule. The first charge-separation moiety includes a material that generates hole-electron pairs in response to being illuminated by light in a first band of wavelengths. After removing any unbound labeling, the working electrode is immersed in a solution containing a compound that is oxidized by the generated holes. The first location is then selectively illuminated with light in the first band; and the change in the current and/or potential is measured between the working electrode and a reference electrode in contact with the solution. The first charge-separation moiety is preferably constructed from particles of a semiconducting material such as TiO2.
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Inaoka Seiji
Roitman Daniel B.
Ward Calvin B.
Le Long V.
Yu Melanie J.
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