Detection of basement membrane components as diagnostic of cance

Details Detection of basement membrane components as diagnostic of cance Detection of basement membrane components as diagnostic of cance

1991-06-26

1993-11-23

Rosen, Sam

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

436503, 436536, G01N 33566

Patent

active

052643700

ABSTRACT:
Methods for the diagnosis of diseases that result in the release of fragments of basement membrane, including fragments, intact molecules and/or complexes of basement membrane components, are disclosed. Detection of basement membrane fragments, intact molecules and/or complexes in a biological fluid by the immunological and physicochemical methods of the present invention allows the diagnosis of a variety of diseases, including cancers, collagen degenerative diseases, and hepatitis. Suitable biological fluids include urine, serum, synovial fluid, and cerebrospinal fluid.

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