Chemistry: analytical and immunological testing – Biological cellular material tested
Patent
1992-07-09
1995-11-28
Parr, Margaret
Chemistry: analytical and immunological testing
Biological cellular material tested
435 10, 435810, 436 8, 436 15, 436 86, 436106, 436173, 436175, 436178, G01N 3352, G01N 3002, G01N 3090, G01N 3096
Patent
active
054707501
ABSTRACT:
Appendicitis can be detected in human beings suspected of having appendicitis by determining a threshold level of 10 mg/liter of .sigma.-hydroxyhippuric acid in the urine of such humans. This threshold level can be determined by qualitative, semiquantitative, or quantitative methods including HPLC (high pressure liquid chromatography), TLC (thin layer chromatography), radioimmunoassay, colorimetric tests, NMR (nuclear magnetic resonance), mass spectrometry, electrophoresis, monoclonal antibody tests, and enzymatic tests. The absence of appendicitis can be established by the presence of .sigma.-hydroxyhippuric acid in concentrations less than about 10 mg/liter in a urine sample.
REFERENCES:
patent: 3915647 (1975-10-01), Wright
Kaplan et al. (1989) Clin Chem Acta, vol. 185, pp. 119-130.
Kapp, E. M. & Coburn, A. F., Urinary Metabolism of Sodium Salicylate-J. Biol. Chem 124: 549-565, 1942.
Altschule, M. D. & Hegedus, Z. L., Ortho-hydroxyhippuric (salicyluric) acid and Itsphysiological and Clinical Significance; Clin. Pharm. and Therapeutics, 15: (2) 111-117 1974.
Appenditech, Inc.
Marschel Ardin H.
Parr Margaret
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