Detection of antibody mediated inflammatory auto-immune...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S029000, C435S007920

Reexamination Certificate

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06936426

ABSTRACT:
The present invention describes a method to detect connective tissue pathologies associated with Graves' disease ophthalmopathy and other antibody mediated inflammatory autoimmune diseases. The detection method comprises obtaining a sample from a patient suffering from an antibody-mediated inflammatory autoimmune disorder and measuring Interleukin 16 (IL-16) or RANTES produced by thyroid associated ophthalmopathy fibroblasts to indicate the presence or severity.

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Sciaky et al. J. Immunol. 2000 164:3806-3814.
Smith et al. Am. J. Pathol. 1997 151:317-322.
Lim et al. J. Immunol. 1996 156:2566-2570.

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