Detection of antibodies to glycosphingolipids using...

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

Reexamination Certificate

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C435S007100, C435S007900, C435S007920, C435S969000, C435S975000, C436S501000, C436S507000, C436S513000, C436S524000, C436S536000, C436S538000, C436S540000, C436S542000, C436S543000, C436S546000, C436S811000

Reexamination Certificate

active

06951763

ABSTRACT:
Methods of detecting antibodies to one or more glycosphingolipid(s) of interest in a sample are disclosed which comprise using a solid-phase reactant having carbonyl groups attached theron, and the glycosphingolipid(s) of interest linked to the solid-phase reactant by an amide bond between an amino group of the glycosphingolipid of interest and a carbonyl group attached to the solid-phase reactant. The methods of detecting antibodies to glycosphingolipid(s) of interest can be used in methods of diagnosing autoimmune diseases in an individual.

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