Detection of antibacterial activity in excretory secretory...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide

Reexamination Certificate

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Reexamination Certificate

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07052874

ABSTRACT:
The present invention provides a heat-stable and protease-resistant antibacterial activity in excretory-secretory products (ESP) ofTrichuris suis. The antibacterial activity is not more than 10,000 MW; is resistant to boiling, trypsin, and pronase E; has a bactericidal mode of action; and is effective against Gram positive and Gram negative bacteria, includingEscherichia coli, Campylobacter jejuni, Campylobactercoli, andStaphylococcus aureus. The antibacterial activity is useful in applications for killing or inhibiting the growth of microorganisms, in particular bacteria.

REFERENCES:
Abner et al. Abstracts of the General Meeting of the American Society for Microbiology. vol. 99, 1999, p. 221.
Rhoads et al. Experimental Parasitology. Jan. 2000, vol. 94, No. 1, pp. 1-7.
Kato et al. Journal of Enzyme Inhibition. 1994, vol. 8, No. 1, pp. 25-37.
Wardlaw et al. Journal of Applied Bacteriology. 1994. vol. 76, pp. 36-41.

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