Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-10-20
1995-08-29
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 74, 435968, 435188, 436811, C12Q 168
Patent
active
054459370
ABSTRACT:
An improved method for diagnosing a disease comprising detecting a disease-specific biochemical marker macromolecule within a sample of extracted cerebral spinal fluid or serum is disclosed. In particular, a radioactively labeled photoaffinity probe is used to diagnose a disease. For instance, Alzheimer's disease can be diagnosed by detecting a disease-specific protein having a molecular weight of about 42,000 daltons, i.e., glutamine synthetase. Also included is a method for detecting other disease states, such as cancer, by detecting the presence or absence of specific nucleotide binding proteins.
REFERENCES:
patent: 5272055 (1993-12-01), Haley
Danman et al., Association-Dissociation of Mammalian Brain Glutamine Synthetase: Effect of Metal Ions and Other Ligands. Archives of Biochemistry and Biophysics 232(2):427-440, 1984.
Gunnerson et al., Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: A potential diagnostic biochemical marker. Proc. Natl. Acad. Sci. USA 89:11949-11953, 1992.
Kepplinger Esther M.
The University of Kentucky Research Foundation
Wortman Donna C.
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