Detection of activated T-cells

Details Detection of activated T-cells Detection of activated T-cells

1985-10-29

1988-11-29

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 4, 435 30, 435 34, 435808, G01N 3353, C12Q 104

Patent

active

047881372

ABSTRACT:
A method of detecting activated T-cells in a population of cells, the method involving determining intracellular calcium ion concentration or intracellular pH in the cells, a calcium ion concentration two-fold or greater above that of resting T-cells, or a pH increase of over 0.2 pH units, indicating activation.

REFERENCES:
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Rabinovitch et al. (Journal of Im-unology, vol. 137, 952-961, No. 3, 1986).
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M. Weiss Proc. Natl. Acad. Sci. USA 81, pp. 6836-6840, 1985.
Meuer et al. (1984) Cell 36: 897-906.

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