Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1985-04-04
1989-04-11
Kepplinger, Esther M.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 11, 424 4, 424 858, 435 7, 435 68, 4351722, 43524027, 435243, 435810, 435948, 436501, 436503, 436504, 436547, 436806, 530387, 530808, 530809, 935 89, 935 93, 935 95, 935106, A61K 4900, G01N 3353
Patent
active
048205052
ABSTRACT:
A diagnostic site-specific imaging reagent in the form of a receptor and an indicating means selectively binds to a specific cell membrane-associated antigen of a blood platelet that is in a stimulated active state but does not substantially bind to a platelet that is in a non-stimulated resting state. In particular, prelabelled monoclonal antibodies and polyclonal antibodies are prepared that bind and image thrombospondin when it is cell membrane-associated on a thrombin-stimulated platelet, thereby providing means for detecting and discriminating between a stimulated active blood platelet and a non-stimulated resting blood platelet.
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Ginsberg Mark H.
Plow Edward F.
Kepplinger Esther M.
Scripps Clinic and Research Foundation
Wieder Stephen C.
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