Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-03-04
1999-11-16
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 231, 536 243, C12Q 168, C07H 2102, C07H 2104
Patent
active
059855479
ABSTRACT:
The identification of a mutation in the HLA-DMB locus in antigen presenting cells defective in presenting antigen is described. Methods of diagnosis and treatment of immunocompromised individuals and compositions and methods of treatment for patients suffering from autoimmune diseases are also described.
REFERENCES:
Brown, et al., "Three-Dimensional Structure of the Human Class II Histocompatibility Antigen HLA-DR1", Nature (1993) 364:33-39.
Calabretta et al., "The Laboratory-Clinic Interface: Prospects for Gene-Directed Therapy With Antisense Oligodeoxynucleotides", Cancer Treatment Reviews (1993) 19:169-179.
Cammarota, et al., "Identification of a CD4 Binding Site on the .beta..sub.2 Domain of HLA-DR Molecules", Nature (1992) 356:799-801.
Ceman, et al., "MHC Class II Deletion Mutant Expresses Normal Levels of Transgene Encoded Class II Molecules That Have Abnormal Conformation and Impaired Antigen Presentation Ability", J. Immun. (1992) 149:754-761.
Chicz, et al., "Specificity and Promiscuity Among Naturally Processed Peptides Bound to HLA-DR Alleles", J. Exp. Med. (1993) 178:27-47.
Chicz, et al., "Predominant Naturally Processed Peptides Bound to HLA-DR1 are Derived From MHC-Related Molecules and are Heterogeneous in Size", Nature (1992) 358:764-768.
Cho, et al., "New Class II-Like Genes in the Muring MHC", Nature (1991) 353:573-576.
Hansen, et al., Leukocyte Typing (1984) (eds. Bernard, A., Boumsell, L., Dausset, J., Milstein, C. and Schlossman, S.) 195 (Springer, Heidelberg).
Cosgrove, et al., "Mice Lacking MHC Class II Molecules", Cell (1991) 66:1051-1066.
Germain, et al., "MHC Class II Structure, Occupancy and Surface Expression Determined By Post-Endoplasmic Reticulum Antigen Binding", Nature (1991) 353:134-139.
Gewirtz, A.M., Leukemia and Lymphoma (1993) 11:131-137.
Griffith, et al., "Structural Mutation Affecting Intracellular Transport and Cell Surface Expression of Murine Class II Molecules", J. Exp. Med. (1988) 167:541-555.
Grusby, et al., "Depletion of CD4.sup.+ T Cells in Major Histocompatibility Complex Class II-Deficient Mice", Science (1991) 253:1417-1720.
Guy, et al., "Differential Expression and Serologically Distinct Subpopulations of Human Ia Antigens Detected With Monoclonal Antibodies to Ia Alpha and Beta Chains", Eur. J. Immun. (1982) 12:942-948.
Harris, E. D., "Rheumatoid Arthritis", New Eng. Jour. Med. (1990) 322:1277-1289.
Hunt, et al., "Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A.sup.d ", Science (1992) 256:1817-1820.
Johnson, et al., "Direct Demonstration of an HLA-DR Allotypic Determinant on the Low Molecular Weight (Beta) Subunit Using a Mouse Monoclonal Antibody Specific for DR3", J. Exp. Med. (1982) 156:104-111.
Johnson, et al., ImmunoBiology of HLA (ed. Dupont, B.O.) (Springer, New York, 1984).
Kelly, et al., "A New Human HLA Class II-Related Locus, DM", J. Nature (1991) 353:571-573.
Konig, et al., "MHC Class II Interaction With CD4 Mediated By a Region Analogous to the MHC Class I Binding Site for CD8", Nature (1992) 356:796-798.
Lampson, et al., "Two Populations of Ia-Like Molecules on a Human B Cell Line", J. Immun. (1980) 125:293-299.
Levine, et al., "Deletion Mapping of HLA and Chromosome 6p Genes", Proc. Natl. Acad. Sci. U.S.A., (1985) 88:3741-3745.
Marsh et al., "HLA Class II Nucleotide Sequences, 1992", Human Immunology (1992) 35:1-17.
Mellins, et al., "Defective Processing and Presentation of Exogenous Antigens in Mutants With Normal HLA Class II Genes", Nature (1990) 343:71-74.
Mellins, et al., "A Gene Required for Class II-Restricted Antigen Presentation Maps to the Major Histocompatibility Complex", J. Exp. Med. (1991) 174:1607-1615.
Mellins, et al., "A Mutant Human Histocompatibility Leukocyte Antigen DR Molecule Associated With Invariant Chain Peptides", J. Exp. Med. (1994) 179:541-549.
Mellins, et al., "Importance of HLA-DQ and -DP Restriction Elements in T-Cell Responses to Soluble Antigens: Mutational Analysis", Hum. Immun. (1987) 18:211-223.
Miller, A. Dusty, "Human Gene Therapy Comes of Age", Nature (1992) 357:455.
Neefjes, et al., EMBO J. (1992) 11:411-416.
Oldstone et al., "Virus Infection Triggers Insulin-Dependent Diabetes Mellitus in a Transgenic Model: Role of Anti-Self (Virus) Immune Response", Cell (1991) 65:319-331.
Orita et al., "Rapid and Sensitive Detection of Point Mutations and DNA Polymorphisms Using the Polymerase Chain Reaction", Genomics (1989) 5:874-879.
Pious, et al., "HLA Class II Regulation and Structure", J. Exp. Med. (1985) 162:1193-1207.
Ratajczak et al., "In Vivo Treatment of Human Leukemia in a Scid Mouse Model With c-myb Antisense Oligodeoxynucleotides", Proc. Nat. Acad. Sci. USA (1992) 89:11823-27.
Riberdy, et al., "HLA-DR Molecules From An Antigen-Processing Mutant Cell Line Are Associated With Invariant Chain Peptides", Nature (1992) 360:474-477.
Sant, et al., "MHC Class II Molecules Express A Targeting Signal That Directs Localization to the Endocytic Compartments of Antigen Presenting Cells", Hum. Immun. (1993) 37s:3.
Sette, et al., "Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant", Science (1992) 258:1801-1804.
Xie, et al., "Rapid, Small-Scale RNA Isolation From Tissue Culture Cells", Bio Techniques, (1991) 11:325-327.
Fling, S.P. et al., "HLA-DMA and -DMB Genes are Both Required for MHC Class II-peptide Complex Formation in Antigen-presenting Cells", Biological Abstracts 1994, vol. 097, Issue 011, Ref. 155379 of Nature vol. 368, pp. 554-558, provided as Biosis No.:97238265.
Morris, P. et al., "An Essential Roel for HLA-DM in Antigen Presentation by Class II Major Histocompatibility Molecules", Biological Abstracts 1994, vol. 097, Issue 011, Ref. 155378 of Nature vol. 368, pp. 551-554, provided as Biosis No.:97238268.
Sanderson, F. et al., "Accumulation of HLA-DM, a Regulator of Antigen Presentation, in MHC Class II Compartments", Science 1994, 266, 1566-1569, provided as Medline No: 09146278 95076278.
Carrington, et al., Characterization of HLA-DMB poly-morphism, Immunogenics 38:446-449 (1993).
Carrington et al. Immunogenetics 38:446-449 (1993).
Nocera et al. Human Immunology 38:231-234(1993).
"Basic Methods in Molecular Biology" Elsevier Science Publishing, Inc., Ed. Davis et al., pp. 62-65 and 143-146 (1986).
Children's Hospital of Philadelphia
Jones W. Gary
Whisenant Ethan
LandOfFree
Detection of a mutation in the HLA-DM.beta. gene in an immunocom does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Detection of a mutation in the HLA-DM.beta. gene in an immunocom, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of a mutation in the HLA-DM.beta. gene in an immunocom will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1322817