Detection method of abnormally-responding lymphocytes as well as

Details Detection method of abnormally-responding lymphocytes as well as Detection method of abnormally-responding lymphocytes as well as

1988-07-27

1993-08-17

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

43524027, 435 72, 435 723, 435 724, 435 792, 436501, 436503, 536123, 530395, C12Q 170, C12Q 100, G01N 3353, G01N 33566, C07G 1700, C07H 100, C08B 3700, C07K 300

Patent

active

052368238

ABSTRACT:
Disclosed herein is a method for the detection of abnormally-responding lymphocytes, e.g., HIV-infected T cells by transformed cells. An antibody, which can specifically recognize a saccharide chain represented by the following formula (I): ##STR1## is caused to act on a sample containing lymphocytes and lymphocytes conjugated with the antibody are then detected. Reagent and kit for the above detection are also disclosed.

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patent: 4904581 (1990-02-01), Burger et al.
patent: 4917998 (1990-04-01), Burger et al.
Hakamori et al, "Novel Fucolipids Accumulating in Human Adenocarcinoma" J. Biol. Chem, 259 (1984) 4672-80.
Adachi et al, "Expression of Le.sup.y Antigen in Human Immunodificiency Virus-Infected Human T Cell Lines and in Peripheral Lymphocytes of Patients with Acquired Immune Deficiency Syndrome (AIDS) and AIDS-Related Complex".
Hakomori, "Glycosphingolipids" Scientific American vol. 254 (1986) 32-42.
Immunogenetics-vol. 17, 1983, pp. 537-541, New York, N.Y. US; K. O. Lloyd et al.

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