Detection method for c-raf-1 genes

Details Detection method for c-raf-1 genes Detection method for c-raf-1 genes

1994-01-24

1997-04-08

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 935 77, 935 78, C12P 1934, C12Q 168

Patent

active

056186703

ABSTRACT:
The present invention relates to (1) a method of identifying an individual at an increased risk for developing cancer, (2) a method for determining a prognosis in patients afflicted with cancer, and (3) a method for determining the proper course of treatment for a patient afflicted with cancer; comprising: amplifying a region of the c-raf-1 gene.

REFERENCES:
McCormick, F. P., et al., "Detection of Point Mutations in Genes Encoding GTP Binding Proteins," WO 91/12343, PCT/US91/00858 (Aug. 22, 1991).
Stetler-Stevenson, M., "A Sensitive Method for Measurement of Chimeric Transcripts of DNA Containing Translocations," WO91/05064, PCT/US90/05427 (Apr. 18, 1991).
Balazs, V., "Malignancy Test (Cancer Test) Using the Polymerase Chain Reaction," WO 90/09456, PCT/DE90/00102 (Aug. 23, 1990).
Bonner, T. I., et al., "The Complete Coding Sequence of the Human raf Oncogene and the Corresponding Structure of the c-raf-1 Gene," Chemical Abstracts, vol. 104, No. 19, p. 141, abstract 162785c, (May 12, 1986) and Nucleic Acids Res. 14(2), 1009-15 (1986).

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