Detection method for C-RAF-1 genes

Details Detection method for C-RAF-1 genes Detection method for C-RAF-1 genes

1997-04-01

1999-02-09

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

536 231, 530350, C12N 912, C07H 2104

Patent

active

058693084

ABSTRACT:
The present invention relates to (1) a method of identifying an individual at an increased risk for developing cancer, (2) a method for determining a prognosis in patients afflicted with cancer, and (3) a method for determining the proper course of treatment for a patient afflicted with cancer; comprising: amplifying a region of the c-raf-1 gene.

REFERENCES:
Mark et al. "Primary structure of v-raf: relatedness to the src family of oncogenes" Science 224:285-298(1984).
Sutrave et al. "Nucleotide sequence of avian retroviral oncogene v-raf" Nature 309:85-88 (1984).
Bonner, T. I., et al., "The Complete Coding Sequence of the Human raf Oncogene and the Corresponding Structure of the c-raf-I Gene" Chemical Abstracts, vol. 104, No. 19, p. 141, abstract 162785c, (May 12, 1986) and Nucleic Acids Res. 14(2), 1009-15 (1986).

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