Chemistry: analytical and immunological testing – Optical result – Including reagent preparation
Reexamination Certificate
2009-07-13
2011-10-18
Gakh, Yelena G (Department: 1777)
Chemistry: analytical and immunological testing
Optical result
Including reagent preparation
C436S063000, C436S164000, C436S172000, C436S518000, C436S527000, C436S805000, C422S082080, C435S287100
Reexamination Certificate
active
08039267
ABSTRACT:
A sensor-chip includes a sensor-portion having at least a metal-layer deposited on a surface of a dielectric-plate. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection-target-substance in a liquid-sample binds onto the sensor-portion. The amount of the detection-target-substance is detected based on the amount of light generated by excitation of a fluorescent-label in the fluorescent-label binding-substance. A fluorescent-substance the charge state of which changes in the liquid-sample according to the pH of the liquid-sample, and which contains a plurality of fluorescent-dye-molecules enclosed by a material that transmits fluorescence output from the fluorescent-dye-molecules, is used as the fluorescent-label. With the fluorescent-label binding-substance bound to the sensor-portion, the fluorescent-label is attracted to the sensor-portion by adjusting the pH of the sample-liquid to neutralize the charge state of the fluorescent-substance, thereby attracting the fluorescent-label onto the sensor-portion. In this state, the amount of the detection-target-substance is detected.
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FUJIFILM Corporation
Gakh Yelena G
Sughrue & Mion, PLLC
Xu Robert
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