Detection as chromosomal translocations by extending and ligatin

Details Detection as chromosomal translocations by extending and ligatin Detection as chromosomal translocations by extending and ligatin

1997-03-14

1999-07-13

Hoblick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 536 2431, C12Q 168, C12P 1934

Patent

active

059225432

ABSTRACT:
A composition and method of producing a composition which is directed to a single nucleic acid comprising a first section complementary to a sequence of a first chromosome, and comprising at least a first label, and a second nucleic acid section complementary to a sequence of a second chromosome, the second label being different from the first label. It is used for detecting translocations such that the single nucleic acid probe has different interactive labels on each side of a translocation break-point region.

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patent: 5427930 (1995-06-01), Birkenmeyer et al.
patent: 5529925 (1996-06-01), Morris et al.
patent: 5567586 (1996-10-01), Croce

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