Detection and treatment of infectious and inflammatory lesions

Details Detection and treatment of infectious and inflammatory lesions Detection and treatment of infectious and inflammatory lesions

1988-07-29

1990-05-15

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 858, 424 8591, 530389, 530402, 252 1, A61K 4902, A61K 4900, A61K 39395

Patent

active

049256483

ABSTRACT:
A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific antibodies or antibody fragments, conjugated to at least one imaging agent, wherein at least two of said antibodies or antibody fragments specifically bind to different leukocyte cell types.
A method for targeting an imaging agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above anti-leukocyte imaging conjugate.
A therapeutic anti-leukocyte antibody-agent conjugate for targeting foci of leukocyte accretion comprises at least one immunoreactive substantially monospecific antibody or antibody fragment which specifically binds to at least one leukocyte cell type, conjugated to at least one therapeutic antimicrobial agent.
A method of treatment of an infectious lesion comprises injecting a mammal parenterally with an effective amount for therapy of the above anti-leukocyte therapeutic conjugate.

REFERENCES:
patent: 4624846 (1986-11-01), Goldenberg
patent: 4634586 (1987-01-01), Goodwin et al.
patent: 4665897 (1987-05-01), Lemelson
patent: 4735210 (1988-04-01), Goldenberg

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