Detection and treatment of infections with immunoconjugates

Details Detection and treatment of infections with immunoconjugates Detection and treatment of infections with immunoconjugates

1993-03-22

1994-07-26

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 2, 424 9, 424 153, 4241361, 4241591, 4241641, 4241781, A61K 4300, A61K 4900, A61K 3900, G01N 100

Patent

active

053325672

ABSTRACT:
A method of targeting a diagnostic or therapeutic agent to a focus of infection comprises injecting a patient infected with a pathogen parenterally with an antibody conjugate which specifically binds to an accessible epitope of the pathogen or of a pathogen-associated antigen accreted at the focus of infection, the antibody conjugate further comprising a bound diagnostic or therapeutic agent for detecting, imaging or treating the infection. Polyspecific composite conjugates enhance the efficacy of the method, which is especially useful for treating infections that are refractory towards systemic chemotherapy.

REFERENCES:
patent: 4671958 (1987-06-01), Rodwell
patent: 4925648 (1990-05-01), Hansen et al.
Costa et al "Immunoglobulin binding to herpes virus-induced FC receptors inhibits virus growth" Nature 269: 251-252, 1977.
Torpier et al "Receptor for IgG(Fc) and human B.sub.2 -Microglobulin on S. Mansoni Schistosomula" Nature 278: 472-449 Mar. 1979.
Goldenberg, National Institutes of Health grant, 1990 5R35CA39841-06, (1984) Federal Research in Progress database.
Vallera, "Immunotoxins for . . . " in Immunotoxins A. Frankel, Ed., Kluwer Pub 1988 pp. 515-535.
Bjorn "Immunotoxins: Selection . . . " Immunotoxins A. Frankel, Ed., Kluwer, pub, 1988 pp. 255-277.
Foung, "Human . . . " J. Infectious Disease vol. 159 (3) pp. 436-443 (Mar. 1989).

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