Detection and treatment of duplex polynucleotide damage

Details Detection and treatment of duplex polynucleotide damage Detection and treatment of duplex polynucleotide damage

1998-08-11

2000-02-29

Nazario-Gonzalez, Porfirio

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 88, 556137, 435 6, 514 44, 514187, 514188, C07F 1500

Patent

active

060310987

ABSTRACT:
Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light. Suitable compound include compounds of the formula:

REFERENCES:
patent: 5157032 (1992-10-01), Barton

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