Detection and recognition of analytes based on their...

Details Detection and recognition of analytes based on their... Detection and recognition of analytes based on their...

2008-05-06

2008-05-06

Gakh, Yelena G. (Department: 1797)

Chemistry: analytical and immunological testing

Process or composition for determination of physical state...

Of crystal or crystalline material

C436S015000, C436S055000, C436S086000, C436S174000, C436S180000

Reexamination Certificate

active

11397908

ABSTRACT:
The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization pattern”) containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a “signature” of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.

REFERENCES:
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Gosalia, D.N. et al., “Printing Chemical Libraries on Microarrays for Fluid Phase Nanoliter Reactions,” Proceedings of the National Academy of Sciences of the United States of America, Jul. 8, 2003, pp. 8721-8726, vol. 100, No. 15, The Scripps Research Institute, La Jolla, CA.
Horoiuchi, K.Y. et al., “Microarrays for the Functional Analysis of the Chemical-Kinase Interactome,” Journal of Biomolecular Screening. Nov. 28, 2005, pp. 1-9, OnlineFirst: 0: 1087057105282097v1, Society for Biomolecular Sciences, Danbury, CT.
Salata, O.V. et al., “Tools of Nanotechnology: Electrospray,” Current Nanoscience, 2005, pp. 25-33, vol. 1, Bentham Science Publishers, Ltd., Oak Park, IL.

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