Chemistry: analytical and immunological testing – Including chromatography
Patent
1993-03-31
1995-04-11
Housel, James C.
Chemistry: analytical and immunological testing
Including chromatography
73 6152, 210656, 436 63, 436175, 436178, G01N 3002
Patent
active
054057825
ABSTRACT:
The present invention relates to an improved method for the determination of therapeutic agents in blood. This method utilizes a solid phase extraction of the solute from plasma followed by reverse phase high performance liquid chromatography on a column of irregularly shaped C-18 modified silica. Comparison of the produced chromatogram with a standard curve provides a precise and accurate quantification of the amount of the solute in blood. Additionally, the extraction and chromatography steps can be readily automated for the rapid determination of multiple samples.
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Kohn Elise C.
Liotta Lance A.
Housel James C.
The United States of America as represented by the Secretary of
Wallenhorst Maureen
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