Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-02-29
1998-09-01
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 78, 435 21, 436501, 436824, 530413, G01N 33535, G01N 33566
Patent
active
058010009
ABSTRACT:
Disclosed is a method of isolating a ligand from a sample, the method including: providing a hybrid molecule including the receptor for the ligand covalently bonded to the first member of a specific binding pair; contacting sample with the hybrid molecule to form an affinity complex between the ligand and the hybrid molecule; and isolating the affinity complex using the second member of the specific binding pair. Also disclosed is a c-kit ligand, nucleic acid encoding such a ligand, and recombinant cells containing such nucleic acid. The c-kit ligand may be used to stimulate hematopoietic cell growth.
REFERENCES:
patent: 4542096 (1985-09-01), Leder
patent: 4859609 (1989-08-01), Dull et al.
patent: 4933294 (1990-06-01), Waterfield et al.
patent: 5109123 (1992-04-01), Reinherz et al.
patent: 5110906 (1992-05-01), Madden et al.
patent: 5116740 (1992-05-01), Sarngadharan et al.
patent: 5126433 (1992-06-01), Madden et al.
patent: 5155027 (1992-10-01), Sledziewski et al.
patent: 5156949 (1992-10-01), Luciw et al.
patent: 5199942 (1993-04-01), Gillis
Young, et al., Proc. Natl., Acad. Sci., USA, vol. 80, Issued Mar. 1983, pp. 1194-1198 "Efficient isolatin of genes by using antibody probes".
Yarden, et al. The EMBO Journal, vol. 6. No. 11, pp. 3341-3351, 1987 "Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand".
J. G. Flanagan et al., Cell, 63, 175-194, 1990.
Flanagan John G.
Leder Philip
President and Fellows of Harvard College
Saunders David
LandOfFree
Detection and isolation of receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Detection and isolation of receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection and isolation of receptors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-269018