Detection and isolation of ligands

Details Detection and isolation of ligands Detection and isolation of ligands

1994-09-14

1996-09-10

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 72, 435 721, 435 723, 435 724, 435 76, 435 78, 435 79, 435 21, 435960, 435963, 436501, 436824, 530413, 935 47, G01N 33535, G01N 33566, G01N 33569, G01N 33574

Patent

active

055544991

ABSTRACT:
Disclosed is a method of isolating a ligand from a sample, the method including: providing a hybrid molecule including the receptor for the ligand covalently bonded to the first member of a specific binding pair; contacting sample with the hybrid molecule to form an affinity complex between the ligand and the hybrid molecule; and isolating the affinity complex using the second member of the specific binding pair. Also disclosed is a c-kit ligand, nucleic acid encoding such a ligand, and recombinant cells containing such nucleic acid. The c-kit ligand may be used to stimulate hematopoietic cell growth.

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