Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1985-11-05
1989-10-24
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 34, 435 35, 4351723, 436 63, 436501, 536 27, 935 29, 935 78, C12Q 168, C07H 1512
Patent
active
048761869
ABSTRACT:
Methods for detecting the presence of Coxiella burnetii in biological samples, as well as a method for differentiating strains of C. burnetii that are capable of causing acute disease from those strains capable of causing chronic disease are disclosed. The methods generally comprise treating cells contained within the biological sample to expose cellular DNA, and hybridizing the cellular DNA (specifically rickettsial DNA) with a C. burnetii-specific labeled DNA probe. Radioisotope and biotin labels are preferred, allowing detection through autoradiography and colorimetric assays, respectively.
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Baca Oswald G.
Frazier Marvin E.
Mallavia Louis P.
Samuel James E.
Battelle Development Corporation
Wagner Richard
Warden Robert J.
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