Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-04-19
2011-04-19
Cheu, Jacob (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007800, C435S174000, C435S182000
Reexamination Certificate
active
07927827
ABSTRACT:
A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
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Doane Kathleen J.
Niehaus Gary D.
Schmidt Steven P.
Signs Steven A.
Woolverton Christopher J.
Cheu Jacob
Do Pensee T
Hahn Loeser & Parks LLP
Kent State University
Oldham, Esq. Scott M.
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