Detecting succinylacetone

Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...

Reexamination Certificate

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C436S178000, C436S177000, C422S430000

Reexamination Certificate

active

07951608

ABSTRACT:
This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry.

REFERENCES:
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Al-Dirbashi et al., “Determination of succinylacetone in dried blood spots and liquid urine as dansylhydrazone by liquid chromatography tandem mass spectrometry,” J. Chrom. B Biomed. Sci. Appl., 831:274-280 (2006).
Allard et al., “Newborn screening for hepatorenal tyrosinemia by tandem mass spectrometry: analysis of succinylacetone extracted from dried blood spots,” Clin. Biochem., 37:1010-15 (2004).
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La Marca et al., “The inclusion of succinylacetone as marker for tyrosinemia type I in expanded newborn screening programs,” Rapid Commun. Mass Spectrom., 22:812-818 (2008).
Magera et al., “Quantitative determination of succinylacetone in dried blood spots for newborn screening of tyrosinemia type I,” Mol. Genet. Metabl., 88:16-21 (2006).
Rashed et al., “Tandem mass spectrometric assay of succinylacetone in urine for the diagnosis of hepatorenal tyrosinemia,” Anal. Biochem., 339:310-317 (2005).
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Schierbeek et al., “Determination of succinylacetone and succinylacetoacetate in physiological samples as the common product 5-3 methyl-3-5-isoxazole propionic acid using an isotope dilution method and mass spectrometry,” Clin. Chim. Acta, 184:243-250 (1989).
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Supplementary European Search Report for EP 08 75 5064, dated Oct. 25, 2010.

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