Chemistry: analytical and immunological testing – For preexisting immune complex or auto-immune disease – Rheumatoid factors
Patent
1983-06-01
1985-10-15
Marantz, Sidney
Chemistry: analytical and immunological testing
For preexisting immune complex or auto-immune disease
Rheumatoid factors
436507, 436533, 436534, 436808, G01N 3354
Patent
active
045474664
ABSTRACT:
A suspension of particles such as carboxylated polystyrene latex particles are coated (as by carbodiimide coupling) with an antigen (such as chemically modified Bovine Serum Albumin). The antigen-coated particles are incubated with a gamma-globulin to the antigen (such as can be produced by immunizing rabbits) under non-agglutinating conditions. The particles having antigen/gamma-globulin immune complexes are recovered and resuspended to form a diagnostic reagent which agglutinates when mixed with human serum containing Rheumatoid Factor.
REFERENCES:
patent: 4143124 (1979-03-01), Masson et al.
patent: 4279617 (1981-07-01), Masson et al.
patent: 4283383 (1981-08-01), Masson et al.
patent: 4332783 (1982-06-01), Pernice et al.
patent: 4427781 (1984-01-01), Masson et al.
Chemical Abstracts, I, 98: 50011y (1983).
J. M. Singer, "The Latex Fixation Test in Rheumatic Diseases" Am. J. of Med., vol. 31, pp. 766-779 (1981).
J. M. Singer et al., "Performance of Latex-Fixation Kits Used for Serologic Diagnosis of Rheumatoid Factor in Rheumatoid Arthritis Sera" Am. J. Clin. Path., vol. 72, No. 4, pp. 597-603, Oct. 1979.
Smith Nathan L.
Turanchik Michael F.
Yeung Kwok K.
Allied Corporation
Doernberg Alan M.
Krawczewicz L.
Marantz Sidney
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