Detecting recurrence and high stage bladder carcinoma

Details Detecting recurrence and high stage bladder carcinoma Detecting recurrence and high stage bladder carcinoma

2006-03-14

2006-03-14

Canella, Karen A. (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007230, C436S063000, C436S064000

Reexamination Certificate

active

07011950

ABSTRACT:
Analysis of nucleophosmin/B23 mRNA expression provides sensitive, quantitative, rapid and specific analysis to detect cancer cells in tissues for predicting and monitoring recurrence and high stage bladder carcinoma. Over-expression of nucleophosmin/B23 mRNA is a useful prognostic marker for disease recurrence and high stages in bladder carcinoma. The use of such prognostic marker for the prediction of bladder tumor recurrence and high stages facilitates more effective management of the cancer.

REFERENCES:
Busch H The Current Status of Studies on Human Tumor Nucleolar Antigens. Cancer Res Monogr, (1987) 4 214-82.
Chung HW Reverse transcriptase PCR (RT-PCR) and quantitative-competitive PCR ((QC-PCR) Exp Mol Med. Apr. 21, 2001;33(1 Suppl):85-97 (abstract only).

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