Detecting particle agglutination with vessel having inclined, st

Details Detecting particle agglutination with vessel having inclined, st Detecting particle agglutination with vessel having inclined, st

1982-07-26

1984-03-13

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

73 641, 356246, 356440, 422 73, 422102, 424 11, 436 63, 436164, 436533, 436805, 436807, G01N 3354, G01N 3380, G01N 2105, G01N 3102

Patent

active

044368275

ABSTRACT:
A particle agglutination reaction is detected with the aid of a reaction vessel of flow cell type having an inlet, an outlet and an inclined passage communicating the inlet and outlet to each other. A test liquid containing particles is supplied into the passage via the inlet and is retained stationary therein for a given time period. Particles descending upon an inclined bottom surface of the passage form at first a stable base layer due to regular steps formed in the bottom surface. When a particle agglutination reaction has occurred, a uniformly deposited particle pattern is formed on the inclined bottom surface, while in case of non-agglutination reaction, the particles descending upon the inclined bottom surface roll down along the base layer and are collected at the lowermost portion of the passage. By detecting the particle pattern formed on the inclined bottom surface, it is possible to detect the agglutination reaction accurately.

REFERENCES:
patent: 3334018 (1967-08-01), Smythe
patent: 4303616 (1981-12-01), Kano
patent: 4373931 (1983-02-01), Takekawa

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