Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-05-23
2006-05-23
Andres, Janet L. (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007950
Reexamination Certificate
active
07049069
ABSTRACT:
Methods for detecting and treating a female reproductive tract disorder relate to the discovery that IL-13 and IL-15 are differentially expressed in biological samples from subjects suffering from a reproductive tract disorder compared to samples from healthy subjects. A female reproductive tract disorder is detected by providing a biological sample derived from the subject; analyzing the expression of IL-13 and/or IL-15 in the sample; and correlating the expression of the cytokine with the presence or absence of the female reproductive tract disorder in the subject. Cytokine expression is modulated in female reproductive tract tissue by contacting the tissue with an agent that modulates expression of IL-13 and/or IL-15 in the tissue.
REFERENCES:
patent: 3997391 (1976-12-01), Ortolani
patent: 5596072 (1997-01-01), Culpepper et al.
patent: 5623555 (1997-04-01), Nelson et al.
patent: 5830453 (1998-11-01), Badr et al.
patent: 5874566 (1999-02-01), Veerapanane et al.
patent: 5985663 (1999-11-01), Bennett et al.
patent: 5986059 (1999-11-01), Shanafelt et al.
patent: 6001973 (1999-12-01), Strom et al.
patent: 6013480 (2000-01-01), Grabstein et al.
patent: 6027720 (2000-02-01), Kuga et al.
patent: 6028176 (2000-02-01), Greve et al.
patent: 6143871 (2000-11-01), Bonnefoy et al.
patent: 6165466 (2000-12-01), Grabstein et al.
patent: 6168783 (2001-01-01), Grabstein et al.
patent: 6177079 (2001-01-01), Grabstein et al.
patent: 6184359 (2001-02-01), Grabstein et al.
patent: 6190901 (2001-02-01), Sundick et al.
patent: WO 99/51643 (1999-10-01), None
Vignali and G. Centinaio, “Studio dell'efficacia della somministrazione di progesterone naturale per via vaginale nella paziente affetta da poliabortivita da causa ormonale, ” Minerva Ginecologica, 52: 367-374, 2000.
Sagol et al., “The Effect of Medroxyprogesterone Acetate and Heparin in the Prevention of Postsurgical Adhesion Formation in the Rat Uterine Model,” J. Obstet. Gynaecol. Res., 25: 287-293, 1999.
Grabstein et al., “Cloning of a T Cell Growth Factor That Interacts with the μ Chain of the Interleukin-2 Receptor,” Science, 264: 965-968, 1994.
Clark and K. Croitoru., “TH1/TH2,3 Imbalance due to Cytokine-Producing NK, γδ T and NK-γδ T cells in Murine Pregnancy Decidua in Success of Failure of Pregnancy,” American Journal of Reproduction Immunology, 45: 257-265, 2001.
Makhseed et al., “Mitogen-Induced Cytokine Responses of Maternal Peripheral Blood Lymphocytes Indicate a Differential Th-Type Bias in Normal Pregnancy and Pregnancy Failure,” American Journal of Reproductive Immunology, 42: 273-281, 1999.
Verma et al., “Human Decidual Natural Killer Cells Express the Receptor for and Respond to the Cytokine Interleukin 15,” Biology of Reproduction, 62: 959-968, 2000.
Odukoya et al., “The Pattern of cytokine mRNA expression in ovarian endometriomata,” Molecular Human Reproduction, 3: 393-397, 1997.
Bedaiwy et al., “Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial,” Human Reproduction, 17: 426-431, 2002.
Makhseed et al., “Circulating cytokines and CD 30 in normal human pregnancy and recurrent spontaneous abortions,” Human Reproduction, 15: 2011-2017, 2000.
Bulfone-Paus et al., “Death deflected: IL-15 inhibits TNF-α-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Rα chain,” The FASEB Journal, 13: 1575-1585, 1999.
Fehniger, T. and Caligiuri, M., “Interleukin 15: biology and relevance to human disease,” Blood, 97: 14-32, 2001.
Jensen, P., “The Interleukin 13 Receptor Complex,” Stem Cells, 18: 61-62, 2000.
Mijatovic et al., “Interleukin-4 and -13 Inhibit Tumor Necrosis Factor-α mRNA Translational Activation in Lipopolysaccharide-induced Mouse Macrophages,” The Journal of Biological Chemistry, 272: 14394-14398, 1997.
Muchamuel et al., “IL-13 Protects Mice from Lipopolysaccharide-Induced Lethal Endotoxemia,” The Journal of Immunology, 158: 2898-2903, 1997.
Di Santo et al., “IL-13 Inhibits TNF Production but Potentiates That of IL-6 In Vivo and Ex Vivo in Mice,” The Journal of Immunology, 159: 379-382, 1997.
de Waal Malefyt et al., “Effects of IL-13 on Phenotype, Cytokine Production, and Cytotoxic Function of Human Monocytes,” The Journal of Immunology, 151:6370-6381, 1993.
Waldmann, T.A. and Tagaya, Y., “The Multifaced Regulation of Interleukin-15 Expression and the Role of This Cytokine in NK Cell Differentiation and Host Response to Intracellular Pathogens,” Annu. Rev. Immunol. 17: 19-49, 1999.
Vainer et al., “Colonic Expression and Synthesis of Interleukin 13 and Interleukin 15 in Inflammatory Bowel Disease,” Cytokine, 12: 1531-1536, 2000.
Okada et al., “Expression of interleukin-15 in human endometrium and decidua,” Molecular Human Reproduction, 6: 75-80, 2000.
Kitaya et al., “IL-15 Expression at Human Endometrium and Decidua,” Biology of Reproduction, 63: 683-687, 2000.
Okada, et al., “Progesterone Enhances Interleukin-15 Production in Human Endometrial Stromal Cells in Vitro,” The Journal of Clinical Endocrinology & Metabolism, 85: 4765-4770, 2000.
McLaren et al., “Decreased levels of the potent regulator of monocyte/macrophage activation, interleukin-13, in the peritoneal fluid of patients with endometriosis,” Human Reproduction, 12: 1307-1310, 1997.
Arici et al., “Increased levels of interleukin-15 in the peritoneal fluid of women with endometriosis: inverse correalation with stage and depth of invasion,” Human Reproduction, 18: 429-432, 2003.
Chegini et al., “Differential Expression of Interleukins (IL)—13 and IL-15 in Ectopic and Eutopic Endometrium of Women With Endometriosis and Normal Fertile Women,” AJRI, 49: 75-83, 2003.
Guerra-infante et al., “Tumor Necrosis Factor in Peritoneal Fluid From Asymptomatic Infertile Womenm” Archives of Medical Research, 30: 138-143, 1999.
Hart et al., “Differential responses of human monocytes and macrophages to IL-4 and IL-13,” Journal of Leukocyte Biology, 66: 575-578, 1999.
Bennett et al., “First-Trimester Human Chorionic Villi Express Both Immunoregulatory and Inflammatory Cytokines: A Role for Interleukin-10 in Regulating the Cytokine Network of Pregnancy,” AJRI, 41: 70-78, 1999.
Ajjan et al., “Detection of IL-12, IL-13, and IL-15 Messenger Ribonucleic Acid in the Thyroid of Patients with Autoimmune Thyroid Disease,” Journal of Clinical Endocrinology and Metabolism, 82: 666-669, 1997.
Chegini Nasser
Ripps Barry
Williams Robert Stanford
Andres Janet L.
Chandra Gyan
Saliwanchik Lloyd & Saliwanchik
University of Florida
LandOfFree
Detecting and treating reproductive tract disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Detecting and treating reproductive tract disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detecting and treating reproductive tract disorders will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3563933