Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2004-08-10
2008-07-22
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S544000, C436S546000, C436S161000, C436S824000, C530S402000, C530S412000
Reexamination Certificate
active
07402397
ABSTRACT:
Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for one or more second proteins in a complex are provided. Upon binding, the cleaving probe is induced to generate an active species, such as singlet oxygen, that cleaves molecular tags attached to the binding compounds only in the local region of the cleaving probe. The released molecular tags are separated from the assay mixture and from one another to provide a readout that is related to the number and types of proteins present in the complex.
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Chan-Hui Po-Ying
Kirakosssian Hrair
Matray Tracy J.
Salimi-Moosavi Hossein
Singh Sharat
Fenwick & West LLP
Haq Shafiqul
Le Long V.
Monogram BioSciences, Inc.
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