Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2009-01-07
2010-12-14
Lam, Ann Y (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S518000
Reexamination Certificate
active
07851173
ABSTRACT:
Detecting and/or measuring a substance based on a resonance shift of photons orbiting within a microsphere of a sensor. Since the resonance of the microsphere has a large quality factor, the sensor is extremely sensitive. The sensor includes the microsphere coupled with at least one optical fiber. The surface of the microsphere includes receptors complementary to the substance. The at least one optical fiber can be provided with at least one additional microsphere having a surface free of the receptors. Resonance shifts observed in such an additional microsphere(s) can be attributed to factors unrelated to the presence of the substance. The resonance shift observed in the microsphere with the receptors can be compensated based on the resonance shift of the additional microsphere(s) to remove the influence of these other factors.
REFERENCES:
patent: 7491491 (2009-02-01), Arnold et al.
patent: 2002/0068018 (2002-06-01), Pepper et al.
Arnold, “Microspheres, Photonic Atoms and the Physics of Nothing”, American Scientist, vol. 89, pp. 414-421.
Arnold Steven
Teraoka Iwao
Lam Ann Y
Pokotylo John C.
Polytechnic Institute of New York University
Straub & Pokotylo
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