Detecting analyte light absorption utilizing degenerate four wav

Optics: measuring and testing – For light transmission or absorption

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356436, 356439, G01N 2100

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active

056004443

ABSTRACT:
A method and apparatus using either two or three input laser beams in a nonlinear degenerate four-wave mixing arrangement for ultrasensative analytical measurements of an analyte. In accordance with a first embodiment of the present invention, a two input beam F-D4WM arrangement is used to generate two phase conjugate signal beams. The input beams are narrowly focused to intersect within a very small volume of an analyte. The analyte may be in any physical state (e.g., liquid, solid, or gas). The intensity of the signal beam is used to detect trace concentrations of particular substances. The beam spot of each of the input beams can be focused to less than 34 .mu.m, thus allowing the present invention to directly focus the input beams within a capillary tube of a HPCE or a column of a HPLC system. In accordance with the second embodiment of the present invention, the input laser beams of a F-D4WM method are directed to points on a lens by immobilized fiber optic cables. In accordance with a third embodiment of the present invention, a three input beam B-D4WM method is used in which the three input laser beams are directed by an immobilized fiber optic cable.

REFERENCES:
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Wu and Tong, "Forward-Scattering Degenerate Four-Wave Mixing As a Simple Sub-Attomole-Sensitive Nonlinear Laser Analytical Spectrometric Method," Anal. Chem. 1993, 65, 112-117.
Wu and Tong, "Laser Analytical Spectrometry Based on Optical Phase Conjugation by Degenerate Four-Wave Mixing in a Flowing Liquid Analyte Cell," Anal. Chem. 1989, 61, 998.
Wu and Tong, "Trace-Concentration Detection of Cobalt in a Liquid Flow Cell By Degenerate Four-Wave Mixing Using Low-Power Off-Resonant Laser Excitation," Anal. Chem. 1991, 63, 1943-1947.

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