Detectably labeled cephalosporin assay for beta-lactamase

Details Detectably labeled cephalosporin assay for beta-lactamase Detectably labeled cephalosporin assay for beta-lactamase

1985-08-23

1988-08-16

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 29, 435 34, 435 38, 435 39, 435188, 435810, C12Q 134, C12Q 102, C12Q 104, C12Q 106, C12Q 110, C12N 996

Patent

active

047644621

ABSTRACT:
This invention provides for a cephalosporin immobilized on a solid phase support comprising a beta-lactamase releasable, detectably labeled substituent at the 3-position thereof.
This invention also provides for an assay for detecting the presence of beta-lactamase enzyme in a sample comprising:

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patent: 4535156 (1985-08-01), Blumbach et al.
Sassiver, M. L. et al., "Structure-Activity Relationships Among the Semisynthetic Antibiotics," (Perlman, D. ed.), N.Y., Academic Press, 1977, pp. 87-160.
Decristoforo, G. et al., "Rapid Determination of Cephalosporins with an Immobilized Enzyme Reactor . . . ", Analytica Chimica Acta, 163 (1984), 73-84.
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Ross et al., Methods for the Study of Antibiotics, Methods of Enzymology, 43, pp. 69-85 (1975).
Lucas, J. of Clinical Pathology, 32, pp. 1061-1065 (1979).
Yolken et al., J. of Pediatrics, 97, pp. 715-720 (1980).
Jones et al., J. of Clin. Microbiol., 15, pp. 677-683 (1982).
Yolken et al., J. of Immunol. Meth., 73, pp. 109-123 (1984).

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