Detectable threading intercalator

Details Detectable threading intercalator Detectable threading intercalator

2005-06-13

2009-08-18

Aulakh, Charanjit S (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C435S006120, C546S002000, C546S066000

Reexamination Certificate

active

07576205

ABSTRACT:
A threading intercalator of general formula I:in-line-formulae description="In-line Formulae" end="lead"?IG1-DG-IG2-(DG-IG3)n  (I)in-line-formulae description="In-line Formulae" end="tail"?wherein IG1, IG2, and IG3are the same or different and represent an intercalating group comprising a planar polyaromatic group; wherein DG represents an electrochemical, a chemiluminescent, a catalytic or an electrochemiluminescent detectable group; and wherein n represents 0 or 1. This invention also relates to a process of detecting a double strand nucleic acid molecule using the threading intercalator.

REFERENCES:
patent: 6399305 (2002-06-01), Makino et al.
patent: 2004/0013959 (2004-01-01), Bender et al.
patent: 2005/0004365 (2005-01-01), Bender et al.
patent: 1 065 278 (2001-03-01), None
CA Abstract No. 144:361123.
CA Abstract No. 144:138765.
CA Abstract No. 143:416889.
CA Abstract No. 141:405195.
CA Abstract No. 140:347297.
CA Abstract No. 125:47474.
CA Abstract No. 142:34147.
CA Abstract No. 140:192948.
CA Abstract No. 138:255498.
CA Abstract No. 138:106994.
CA Abstract No. 136:336733.
CA Abstract No. 140:321690.
CA Abstract No. 138:90397.
CA Abstract No. 132:194027.
CA Abstract No. 81:169931.
CA Abstract No. 81:152670.
CA Abstract No. 139:204923.
CA Abstract No. 138:39267.
CA Abstract No. 132:161722.
CA Abstract No. 127:220962.
U.S. Appl. No. 10/866,370, filed Jun. 10, 2004, Gao et al.
Shau-Fong Yen et al. “Interaction of Aromatic Imides with Deoxyribonucleic Acid. Spectrophotometric and Viscometric Studies”.Biochemistry(1982), 21, 2070-2076.
Natalia C. Tansil et al. “Direct Detection of DNA with an Electrocatalytic Threading Intercalator”.Anal. Chem., vol. 77, No. 1, (2005), 126-134.
Joseph Wang. Survey and Summary From DNA Biosensors to Gene Chips.Nucleic Acids Research, 2000, vol. 28, No. 16, 3011-3016.
T. Gregory Drummond et al. “Electrochemical DNA sensors”.Nature Biotechnology, vol. 21, No. 10, (2003), 1192-1199.
Emil Pale{hacek over (c)}ek et al. “Electrochemistry of Nucleic Acids and Development of DNA Sensors”.Critical Reviews in Analytical Chemistry, 32(3):261-270 (2002).
Frantisek Jelen et al. “Label-Free Determination of Picogram Quantities of DNA by Stripping Voltammetry with Sold Copper Amalgam or Mercury Electrodes in the Presence of Copper”.Anal. Chem., vol. 74, No. 18, (2002), 4788-4793.
Grant R. Sutherland et al. “The Study and Diagnosis of Human Genetic Disorders using Nucleic Acid Probes”.Nucleic Acid Probes, Synoms, R.H. Ed.; CRC Press, Boca Raton, FL., (1989), 159-201.
Larry J. Kricka. “Nonisotopic Probing, Blotting, and Sequencing”. 2ndEd. Academic Press Inc., San Diego, CA, (1995), 41-109.
Wujan Miao et al. “Electrogenerated Chemiluminescence. 72. Determination of Immobilized DNA and C-Reactive Protein on Au(111) Electrodes Using Tris(2,2′-bipyridyl)ruthenium(II) Labels”.Anal. Chem. vol. 75, No. 21, (2003), 5825-5834.
Thomas J. Meyer. “Chemical Approaches to Artificial Photosynthesis”.Acc. Chem. Res., vol. 22, No. 5, (1989), 163-170.
Jonathan V. Caspar et al. “Photochemistry of Ru(bpy)32+, Solvent Effects”.J. Am. Chem. Soc. (1983), vol. 105, No. 17, 5583-5590.
J. Van Houten et al. “Temperature Dependence of the Photophysical and Photochemical Properties of the Tris(2,2′-bipyridyl)ruthenium(II) Ion in Aqueous Solution”.J. Am. Chem. Soc. (1976), 98:16, 4853-4858.
Nurhan E. Tokel et al. “Electrogenerated Chemiluminescence. IX. Electrochemistry and Emission from Systems Containing Tris(2,2′-bipyridine)ruthenium(II) Dichloride1”.J. Am. Chem. Soc. 94:8, (1972), 2862-2863.
Wujian Miao et al. “Electrogenerated Chemiluminescence. 80. C-Reactive Protein Determination at High Amplification with [Ru(bpy)3]2+-Containing Microspheres”.Anal. Chem. (2004), 76, 7109-7113.
Wujian Miao et al. “Electrogenerated Chemiluminescence. 77. DNA Hybridization Detection at High Amplification with [Ru(bpy)3]2+-Containing Microspheres”,Anal. Chem. (2004), 76, 5379-5386.
Koji Hashimoto et al. “Sequence-Specific Gene Detection with a Gold Electrode Modified with DNA Probes and an Electrochemically Active Dye”.Anal. Chem. (1994), 66, 3830-3833.
Michael T. Carter et al. “Voltammetric Studies of the Interaction of Metal Chelates with DNA. 2. Tris-Chelated Complexes of Cobalt(III) and Iron(II) with 1,10-Phenanthroline and 2,2′-Bipyridine”.J. Am. Chem. Soc. (1989), 111, 8901-8911.
Steven M. Zenman et al. “Characterization of Covalent Adriamycin-DNA Adducts”.Proc. Natl. Acad. Sci. USA 95 (1998) 11561-11565.
Kathryn E. Erkkila et al. “Recognition and Reaction of Metallointercalators with DNA”.Chem. Rev. (1999), 99, 2777-2795.
Andreas Rademacher et al. English Abstract of “Lösliche Perylen-Fluoreszenzfarbstoffe mit hoher Photostabilität”.Chem. Ber. 115, 2927-2934 (1982).
Howard E. Katz et al. “Naphthalenetetracarboxylic Diimide-Based n-Channel Transistor Semiconductors: Structural Variation and Thiol-Enhanced Gold Contacts”.J. Am. Chem. Soc. (2000), 122, 7787-7792.
Hong Xie et al. “A Nucleic Acid Biosensor for Gene Expression Analysis in Nanograms of mRNA”.Anal. Chem. (2004), 76, 4023-4029.
Hong Xie, et al. “Amperometric Detection of Nucleic Acid at Femtomolar Levels with a Nucleic Acid/Electrochemical Activator Bilayer on Gold Electrode”.Anal. Chem. (2004), 76, 1611-1617.
Hong Xie et al. “Highly Sensitive Amperometric Detection of Genomic DNA in Animal Tissues”.Nucleic Acids Research(2004), vol. 32, No. 2 e15.
Adam B. Steel et al. “Electrochemical Quantitation of DNA Immobilized on Gold”.Anal. Chem. 1998, 70, 4670-4677.
A. Juris et al. “Ru(II) Polypyridine Complexes: Photophysics, Photochemistry, Electrochemistry, and Chemiluminescence”.Coordination Chemistry Reviews, 84 (1988) 85-277.
Dabney W. Dixon et al. “Effect of DNA Scaffolding on Intramolecular Electron Transfer Quenching of a Photoexcited Ruthenium(II) Polypyridine Naphthalene Diimide”.Inorg. Chem. 1999, 38, 5526-5534.
Dale L. Boger et al. “A Simple, High-Resolution Method for Establishing DNA Binding Affinity and Sequence Selectivity”.J. Am. Chem. Soc. (2001), 123, 5878-5891.
Meredith M. Murr et al. “AnOctakis-Intercalating Molecule”.Bioorg. Med. Chem9 (2001), 1141-1148.
Shigeori Takenaka et al. “DNA Sensing on a DNA Probe-Modified Electrode Using Ferrocenylnaphthalene Diimide as the Electrochemically Active Ligand”.Anal. Chem. 2000, 72, 1334-1341.
Diego A. Gianolio et al. “Tethered naphthalene diimide-based intercalators for DNA triplex stabilization”,Nucleic Acids Research, 2000, vol. 28, No. 19.
Shigeori Takenaka et al. “Selective stabilization of a bulged duplex of d(GCGAAACGC) oligonucleotide by thymine base-substituted naphthalene diimide”.Chem. Commun., 1997, 115-116.

Affiliated with

Also associated with

Rating

Detectable threading intercalator does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Detectable threading intercalator, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detectable threading intercalator will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4083682