Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-08-02
1998-06-09
Low, Christopher S. F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 44, 514 2, 424 9321, 424 931, 4352351, 435325, 435 691, 4351723, A61K 4800
Patent
active
057634157
ABSTRACT:
The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The methods comprise contacting the ductal epithelium of the exocrine gland with an epithelium-destroying agent, preferably by ductal cannulation, so as to realize a prophylactic or therapeutic effect.
REFERENCES:
patent: 5215904 (1993-06-01), Gould et al.
patent: 5304489 (1994-04-01), Rosen
Berchem et al., Cancer Research, 55:735-738 (Feb. 15, 1995).
Bieche et al., Cancer Research, 54:4274-4276 (Aug. 15, 1994).
Chen et al., Proc. Natl. Acad. Sci. USA, 91:3054-3057 (Apr. 1994).
Fujiwara et al., Current Opinion in Oncology, 6:96-105 (1994).
Hanby et al., Proc. Annu. Meet. Am. Assoc. Cancer Res., 35:A1085 (1994).
Haran et al., Cancer Research, 54:5511-5514 (Nov. 1, 1994).
Manome et al., Cancer Research, 54:5408-5413 (Oct. 15, 1994).
Miyadera et al., Cancer Research, 55:1687-1690 (Apr. 15, 1995).
Osaki et al., Cancer Research, 54:5258-5261 (Oct. 15, 1994).
Pansera, Medical Hypotheses, 33:107-111 (1990).
Pitts, Molecular Carcinogenesis, 11:127-130 (1994).
Frykberg et al., "Overview of the Biology and Management of Ductal Carcinoma in Situ of the Breast," Database Medline, File Server Stn Karlsruhe, Abstract 94273121 (1994).
Russo et al., "Biology of Disease. Comparative Study of Human and Rat Mammary Tumorigenesis," Laboratory Investigation, vol. 62, pp. 244-278 (1990).
Tamaki et al., "A Human Monoclonal Antibody Derived from Axillary Lymph Nodes of a Breast Cancer Patient," Hybridoma, vol. 8, pp. 293-302 (1989).
Tamm et al., "Interleukin 6 Decreases Cell-Cell Association and Increases Motility of Ductal Breast Carcinoma Cells," The Journal of Experimental Medicine, vol. 170, pp. 1649-1669 (Nov., 1989).
Zenklusen et al., "The Immunohistochemical Reactivity of a New Anti-Epithelial Monoclonal Antibody (MAb b-12) Against Breast Carcinoma and Other Normal and Neoplastic Human Tissues," Virchows Archiv A Pathological Anatomy and Histopathology, vol. 413, pp. 3-10 (1988).
Orkin et al. Report and Recomendations . . . Gene Therapy. NIHPress. Dec. 7, 1995. p. 1-40.
Miller et al. FASEB. vol. 9 :190-199, Feb. 1995.
Marshall. Science.269:1050-1055, Aug. 1995.
Culver et al. TIG. 10(5):174-178, May 1994.
Hodgson. Exp Opin Ther. Patents. 5(5):459-468, 1995.
LaFont et al. The Lancet. 346: 1442-1443, Dec. 1995.
Friedmann Cancer (supp) vol.70(6):1810-1816, Sep. 1992.
John Hopkins University School of Medicine
Low Christopher S. F.
Nguyen Dave T.
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