Desoxyribonucleic acid; microorganisms; diagnostic agent for del

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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435 6, 435 7, 4351723, 435320, 436501, 436811, 436813, 935 3, 935 29, 935 56, 935 78, C07H 2104, C12Q 168, C12N 1500, G01N 3353

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active

049594621

ABSTRACT:
This invention relates to DNA having at least 60% homology relative to .gamma.-RNA or a portion thereof and the capacity of selective hybridization with .delta.-RNA. Such DNA, if provided with a detectable label, such as .sup.32 P can be used as a diagnostic agent to diagnose .delta. infection.

REFERENCES:
patent: 4619896 (1986-10-01), Shattock et al.
patent: 4711955 (1987-12-01), Ward et al.
Tiollais, P. et al. (1985), Nature, 317, pp. 489-495.
Richman, D. D. et al. (1984), J. of Infectious Diseases, 149(3), pp. 298-310.
Chemical Abstracts, vol. 100, No. 21, 21st May 1984, p. 328, col. 1, Abstract No. 171214k, Columbus, Ohio, U.S.; B. Hoyer et al.: "Properties of Delta-Associated Ribonucleic Acid"; & Prog. Clin. Biot. Res., vol. 143, 1983, pp. 92-97.
Chemical Abstracts, vol. 104, No. 21, 26th May 1986, p. 326, cols. 1, 2, Abstract No. 182922y, Columbus, Ohio, U.S., Ne. Cen. Org. voor Toegepast-Natuurwetenschappelijk Onderzoek; "Deoxyribonucleic Acid, Microorganisms, Diagnositc Means for Delta Infection, and Use There Of"; N.A. 8402392 published 17th Feb. 1986, priority 31st Jul. 1984.
Chemical Abstracts, vol. 105, No. 1, 7th Jul. 1986, p. 149, col. 2, Abstract No. 1518y, Columbus, Ohio, U.S.: K. J. Denniston et al.: "Cloned Fragment of the Hepatitis Delta Virus RNA Genome: Sequence and Diagnostic Application"; & Science vol. 232, 1986, pp. 873-875.
Chemical Abstracts, vol. 100, No. 17, 23rd Apr. 1984, p. 481, col. 2, Abstract No. 137082f, Columbus, Ohio, U.S.; F. Bonino et al.: "Delta Hepatitis Agent: Structural and Antigenic Properties of the Delta Associated Particle"; & Infect. Immun., vol. 43, No. 3, 1984, pp. 1000-1005.
Wang et al, Nature, 323, 508-514 (1986).
Denniston et al, The Chemical Abstracts 105:1518y (1986).

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