Designed quinone- and hydroquinone-containing cyclic enediyneols

Organic compounds -- part of the class 532-570 series – Organic compounds – Polycyclo ring system containing anthracene configured ring...

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Details

536 254, 552298, 552299, C07C 5006, C07C 5014, C07C 5020

Patent

active

052741419

ABSTRACT:
Quinone- and hydroquinone-containing cyclic enediyneols and enediyneones having 10-carbon atoms in the enediyne-containing ring that cleave DNA are disclosed, as are methods of making and using the same.

REFERENCES:
patent: 5136099 (1992-08-01), Skokotas et al.
patent: 5183942 (1993-02-01), Nicolaou et al.
Nicolaou et al., J. Am. Chem. Soc., 110:4866-4868 (1988).

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