Design of artificial genes for use as controls in gene...

Details Design of artificial genes for use as controls in gene... Design of artificial genes for use as controls in gene...

2005-09-13

2005-09-13

Fredman, Jeffrey (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024100, C536S024300, C536S024310, C536S024330, C435S006120

Reexamination Certificate

active

06943242

ABSTRACT:
Method of producing controls for use in gene expression analysis systems such as macroarrays, real-time PCR, northern blots, SAGE and microarrays. The controls are generated either from near-random sequence of DNA, or from inter- or intragenic regions of a genome. Ten specific control sequences are also disclosed. Also presented are methods of using these controls, including as negative controls, positive controls, and as calibrators of a gene expression analysis system.

REFERENCES:
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Beibbarth, T., et al. “Processing and Quality Control of DNA Array Hybridization Data” Bioinformatics 2000, vol. 12, No. 11, pp. 1014-1022.

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