Design and synthesis of optimized ligands for PPAR

Details Design and synthesis of optimized ligands for PPAR Design and synthesis of optimized ligands for PPAR

2008-03-04

2008-03-04

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S369000

Reexamination Certificate

active

07339065

ABSTRACT:
This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.

REFERENCES:
patent: WO 02/076177 (2002-10-01), None
Schiffrin, Am. J. Physiol. Heart Circ. Physiol., (2005), 288, pp. H1037-H1043.
Staels et al., Diabetes, (Aug. 2005), vol. 54, pp. 2460-2470.
McGeer, Biodrugs, 2005, 19(1), pp. 31-37.

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