Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2007-08-22
2010-02-23
Smith, Carolyn L. (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C702S033000, C702S179000, C703S002000, C703S011000, C706S013000, C706S048000, C707S793000, C707S793000, C435S006120, C435S287200, C435S288400
Reexamination Certificate
active
07668664
ABSTRACT:
A computer-implemented method as follows. Providing a list of target sequences associated with one or more organisms. Providing a list of candidate prototype sequences suspected of hybridizing to one or more of the target sequences. Generating a collection of probes corresponding to each candidate prototype sequence, each collection of probes having a set of probes for every subsequence. The sets consist of the corresponding subsequence and every variation of the corresponding subsequence formed by varying a center nucleotide of the corresponding subsequence. Generating a set of fragments corresponding to each target sequence. Calculating the binding free energy of each fragment with a perfect complimentary sequence of the fragment. Determining which extended fragments are perfect matches to any of the probes. Assembling a base call sequence corresponding to each candidate prototype sequence.
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Counterpart PCT Search Report and Written Opinion.
Lin Baochuan
Malanoski Anthony P.
Schnur Joel M
Stenger David A
Wang Zheng
Grunkemeyer Joseph T.
Karasek John J.
Smith Carolyn L.
The United States of America as represented by the Secretary of
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