Desensitized aspartokinase

Details Desensitized aspartokinase Desensitized aspartokinase

2005-05-17

2005-05-17

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

C435S252300, C435S194000, C435S320100, C435S252320, C435S471000, C435S478000, C536S023200, C562S562000

Reexamination Certificate

active

06893848

ABSTRACT:
The present invention relates to a novel aspartokinase derived from a Coryneform bacterium; a DNA encoding the enzyme; a recombinant DNA containing the above DNA; a Coryneform bacterium having the above recombinant DNA or a Coryneform bacterium having the DNA on its chromosome; and a process for producing L-lysine by culturing the above microorganism. Construction has been successfully made of a DNA encoding an aspartokinase freed from concerted feedback inhibition by L-lysine and L-threonine derived from aCorynebacteriumand has a nucleotide sequence encoding an amino acid sequence wherein the amino acid residue at position 311 is an amino acid other than Thr in the amino acid sequence shown by SEQ ID NO: 18.

REFERENCES:
patent: 3708395 (1973-01-01), Nakayama et al.
patent: 4623623 (1986-11-01), Nakanishi et al.
patent: 4657860 (1987-04-01), Nakanishi et al.
patent: 5236831 (1993-08-01), Katsumata et al.
patent: 5688671 (1997-11-01), Sugimoto et al.
patent: 259858 (1988-03-01), None
patent: 0 699 759 (1996-03-01), None
patent: 59-88094 (1984-05-01), None
patent: 63-62199 (1988-12-01), None
patent: 5-11959 (1993-02-01), None
patent: 5-5514 (1993-08-01), None
patent: 6-62866 (1994-03-01), None
patent: 6-261766 (1994-09-01), None
patent: 7-55155 (1995-06-01), None
patent: 9425605 (1994-11-01), None
“Amino Acid Fermentation”, Japan Scientific Societies Press (1986), p273 (with partial English translation).
Follettie, et al., “Gene Structure and Expression of the Corynebacterium”, Journal of Bacteriology, vol. 175, No. 13 (1993), pp. 4096-4103.
Kalinowski, et al., “Genetic and biochemical analysis of the . . . ”, Molecular Microbiology, vol. 5, No. 5 (1991), pp. 1197-1204.
Enei, et al., “Recent Progress in Microbial Production of Amino Acids” (1989), pp. 47-53.
Leuchtenberger, “Amino-Acids—Technical Production and Use”, pp. 474-482.

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