Descendants of bacteria devoid of N terminal formylation...

Details Descendants of bacteria devoid of N terminal formylation... Descendants of bacteria devoid of N terminal formylation...

2005-07-08

2008-07-15

Ketter, James S (Department: 1636)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S252330

Reexamination Certificate

active

07399611

ABSTRACT:
Eubacterial cells which produce non-formylated proteins, polypeptides and/or peptides and methods for making such non-formylated products. The eubacterial cells may be produced by inactivating or deleting the def (deformylase) and/or fmt (Met-tRNA transformylase) gene(s) from the def-fmt operon of the corresponding wild-type strain.

REFERENCES:
patent: 6962807 (2005-11-01), Marliere et al.
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Thierry Meinnel, et al., “Structure-Function Relationships within the Peptide Deformylase Family. Evidence for a Conserved Architecture of the Active Site Involving Three Conserved Motifs and a Metal Ion,” J. Biol. Mol. (1997), vol. 267, pp. 749-761.
Andreas Kreusch, et al., “Structure Analysis of Peptide Deformylases fromStreptococcus pnewmoniae, Straphylococcus aureaus, Thermotoga maritima and Pseudomonas aeruginosa: Snapshots of the Oxygen Sensitivity of Peptide Deformylase,” J. Mol. Biol. (2003), vol. 330, pp. 309-321.
Didier Mazel, et al., “A Survey of Polypeptide Deformylase Function Throughout the Eubacterial Lineage,” J. Mol. Biol. (1997), vol. 266, pp. 939-949.
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D. Mazel, et al., EMBO Journal, vol. 13, No. 4, pp. 914-923, XP-002043973, “Genetic Characterization of Polypeptide Defomylase, A Distinctive Enzyme of Eubacterial Translation”, Feb. 15, 1994.
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