Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1985-11-19
1987-08-18
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530315, 514807, A61K 3734, C07K 716
Patent
active
046877584
ABSTRACT:
Peptides having vasopressin antagonist activity are prepared by a peptide synthesizer to insert a N-methylarginine at the 7-position of the structure. An example of this series of compounds is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-7-desproline-8-N-methylarginine-9-de sglycine]-vasopressin.
REFERENCES:
patent: 4481193 (1984-11-01), Ali et al.
patent: 4481194 (1984-11-01), Ali et al.
patent: 4543349 (1985-09-01), Callahan et al.
patent: 4599324 (1986-07-01), Ali et al.
patent: 4604378 (1986-08-01), Callahan et al.
Ali Fadia E.
Huffman William F.
Marshall Garland R.
Moore Michael L.
Daniel Mark R.
Lourie Alan D.
Phillips Delbert R.
SmithKline Beckman Corporation
Williams Janice E.
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