Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Reexamination Certificate
1998-04-06
2001-07-31
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
C424S070100, C424S070600, C424S070900, C424S401000, C514S557000, C514S724000, C514S725000, C514S728000
Reexamination Certificate
active
06267948
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to enhancing the pigmentation response to inducers of melanogenesis by inclusion of melanogenesis-enhancing agents in formulations applied to skin, hair, wool or fur.
2. Description of the Related Art
There have been various descriptions of the use of compounds for stimulating melanogenesis or pigmentation. U.S. Pat. No. 5,352,440 describes increasing melanin synthesis in melanocytes and increasing pigmentation by administration of certain diacylglycerol compounds. Increased pigmentation in mammalian skin via administration of certain DNA fragments is disclosed in U.S. Pat. No. 5,532,001. U.S. Pat. No. 5,554,359 is directed to increasing levels of melanin in melanocytes by administration of lysosomotropic agents. And various melanogenic diols are described in Brown et al., 1998, J. Invest. Dermatol., 110:428-427.
While certain methods and compositions for stimulating pigmentation are known, there exists a need for improvements in the art. The present invention provides improved methods and compositions for stimulating pigmentation responses in mammalian skin, hair, wool or fur.
SUMMARY OF THE INVENTION
The present invention provides a method for increasing the pigmentation response of mammalian skin, hair, wool or fur to agents which stimulate melanogenesis, comprising administering to mammalian skin, hair, wool or fur a dermatological formulation comprising a melanogenesis-stimulating effective amount of an agent which stimulates melanogenesis in melanocytes, and a melanogenesis-enhancing effective amount of an agent which enhances the stimulation of melanogenesis by the melanogenesis-stimulating agent. More particularly, the melanogenesis-enhancing compounds are selected from among &agr;-hydroxy acids, salts and derivatives thereof; &agr;-keto acids, salts and derivatives thereof; &bgr;-hydroxy acids, salts and derivatives thereof; retinoids, salts and derivatives thereof; Vitamin A and related compounds; acids such as trichloroacetic acid and trifluoroacetic acid; phenol; and, methoxypropyl-gluconamide.
Another aspect of the present invention provides a dermatological formulation for increasing the pigmentation response of mammalian skin, hair, wool or fur to agents which stimulate melanogenesis. The formulation comprises a melanogenesis-stimulating effective amount of an agent which stimulates melanogenesis in melanocytes, and a melanogenesis-enhancing effective amount of an agent which enhances the stimulation of melanogenesis by the melanogenesis-stimulating agent. More particularly, the melanogenesis-enhancing compounds are selected from among &agr;-hydroxy acids, salts and derivatives thereof; &agr;-keto acids, salts and derivatives thereof; &bgr;-hydroxy acids, salts and derivatives thereof; retinoids, salts and derivatives thereof; Vitamin A and related compounds; acids such as trichloroacetic acid and trifluoroacetic acid; phenol; and, methoxypropyl-gluconamide.
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Brown David A.
Ren Wu Yun
Seidman Michael
Applied Genetics Incorporated Dermatics
Dodson Shelley A.
Klee Maurice M.
Lamm Marina
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