Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Skin cosmetic coating
Patent
1994-05-18
1996-11-19
Killos, Paul J.
Drug, bio-affecting and body treating compositions
Topical body preparation containing solid synthetic organic...
Skin cosmetic coating
514844, 514847, A61K 700, A61K 748, A61K 706
Patent
active
055759947
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/EP92/02597 filed Nov. 12, 1992.
The present invention relates to dermatological and cosmetic compositions and particularly to compositions having antiageing activity; said compositions are also useful in the treatment of burns, wounds and are characterized by a high stability such as to make them also suitable for the stabilization of active ingredients.
Skin is formed by cells the state of which affects the external appearance of epidermis. Skin ageing derives from a slowing of the derm functions, particularly nutrition, respiration, hydration, regeneration and cutaneous tissues protection. Skin ageing is a natural phenomenon the causes of which are of different origin and can be more or less fast for each person. Generally, the function slowing of certain cells, the role of which is very important in maintaining the integrity of derm structure, begins around one's thirties. This phenomenon may begin at a more or less early age, due to many factors, such as genetic set, general health state, each individual's peculiar way of life.
The object of the present invention is to provide dermatological and cosmetic compositions having antiageing activity and having high stability, also in the presence of active ingredients of various kind.
The compositions according to the invention consist of:
______________________________________ 1) emulsifying and self-emulsifying agents, having
o/w activity formed by a mixture containing
(as % w/w)
1') polyethylene glycol mono- or distearate
0.5-5.0%
2') polyglycol esters of saturated or
1.0-10.0%
unsaturated C.sub.14 -C.sub.20 fatty acids
3') cetyl alcohol and optionally other
1.0-16.0%
higher alcohols, comprising free
or esterified sterols
2) sodium versenate and antioxidant agents
0.1-5.0%
3) anti-mould and bacteriostatic agents
0.05-0.1%
4) active ingredients having derm reconstituting
1-30%
activity
5) purified water F.U. q.s. to 100%
______________________________________
Polyethylene glycols, having various molecular weight, weight, for example ranging from 200 to 10,000, preferably from 400 to 2,000, more preferably 1,000, can be used. Polyethylene glycol 1,000 monostearate is particularly preferred.
The antioxidant agents are selected from the group consisting of:
Examples of anti-mould and/or bacteriostatic agents are methyl or propyl p-oxybenzoates.
The active ingredients preferably have derm reconstituting activity. Examples of said active ingredients, which can be used alone or combined each other, are collagen, in the several forms thereof, esurosamine, elastin, amino acids, peptides, mucopolysaccharides.
The compositions of the invention are characterized by a remarkable eudermicity, therefore, they act in an extraordinarily favourable extent on skin stretching and smoothness (anti-wrinkle effect), translucency, on tissue stiffening, turgidity and elasticity, on the reduction of irregular fat accumulation in subcutaneous connective ("cellulitis"). The same favourable effects are exerted by the compositions on skin irritations on children, due to wet linens or sweat, on feet irritations due to maceration, on sun-induced irritations.
Further, the compositions of the invention also carry out a surprising dermatological activity on burns, crural ulcer, wound healings, bedsores, accelerating their recovery.
A particular and surprising aspect of the present invention lies in the fact that the above mentioned compositions, with a formulation excluding the active ingredients of the above point 4, act as stabilizing carriers towards several active ingredients, such as vitamins, hormones, antibiotics. Accordingly, said compositions are useful for the preparation of pharmaceutical compositions containing active ingredients, which are subject to degradation due to environmental conditions (temperature, humidity, oxidants, etc.).
Several stability tests, through chromatographic analysis, established that the compositions of the invention maintain the titre of the active ingredients therein enclose
REFERENCES:
patent: 4883792 (1990-11-01), Timmins et al.
CA 107:102711 1987.
CA 114:192632 1990.
CA 77:39054 1971.
CA 115:214871 1991.
Istituto Gentili S.p.A.
Killos Paul J.
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